We are Surgeons for children (Infant-us): result of the use of Senosides as a stimulant laxative, in the intestinal rehabilitation program
DOI:
https://doi.org/10.5281/zenodo.11388213Keywords:
sennosides, chronic functional constipation, laxativeAbstract
Sennosides, which are specifically extracted from the pericarp of cassia acutifolia (also known as Senna of Alexandria), are active glycoside compounds that consist of a complex bonding of sugars with the anthraquinone derivative rhein. These compounds have made it possible to standardize senna extracts, a plant recognized since ancient times for its effectiveness as a laxative, and which is characterized by lacking unwanted side effects. Sennosides A and B are substances that act as laxatives by increasing the activity of the muscles of the intestine by stimulating the nerve endings present in the intestinal wall. When this medication is used, the movement of intestinal contents is accelerated, leading to relief from constipation by facilitating faster transit along the intestinal tract. It takes 6 to 10 hours for this medication to work. This study was planned to analyze and determine the effectiveness of sensorosides in treating chronic functional constipation in pediatric patients. The main objective of this study is to obtain the results of the use of sinosides as a stimulant laxative in pediatric patients. The methodological strategies used was the study of the medical records obtained from Infant-us since 2017 where we obtained the relevant data and used the Excel program to process and analyze the results. A successful response of 85% to the use of sinuses as a stimulant laxative was demonstrated in patients in the "intestinal rehabilitation" program.
Downloads
References
Aguirre-Raya, K. A., Toro, E., & Ramírez-Mayans, J. A. (2023). Tratamiento del estreñimiento funcional en pediatría. NeuroGastroLATAM Reviews, 5(1). https://doi.org/10.24875/ngl.19000039
Bokova, E., Prasade, N., Rosen, J. M., Lim, I. I. P., Levitt, M. A., & Rentea, R. M. (2023). State of the Art Bowel Management for Pediatric Colorectal Problems: Spinal Anomalies. Children, 10(9). https://doi.org/10.3390/children10091558
Carballido, E. (2021, December 9). Propiedades de las Antraquinonas. Botanical Online. https://www.botanical-online.com/plantas-medicinales/sustancias-antraquinonas
de Geus, A., Koppen, I. J. N., Flint, R. B., Benninga, M. A., & Tabbers, M. M. (2023). An Update of Pharmacological Management in Children with Functional Constipation. In Pediatric Drugs (Vol. 25, Issue 3, pp. 343–358). Adis. https://doi.org/10.1007/s40272-023-00563-0
DrTango, I. (2022, August 11). Cómo usar medicamentos de venta libre de manera segura. Medline Plus: Biblioteca Nacional de Medicina. https://medlineplus.gov/spanish/ency/patientinstructions/000882.htm
Duncan, A. (1956). Speaking at the Royal Institution in London STANDARDIZED SENNA AS A LAXATIVE IN THE PUERPERIUM A CLINICAL ASSESSMENT. J. Pharm. Pharmacol, 2(807), 115.
Endrick, M. (2020, April 28). Propiedades del SEN. Botanical Online. https://www.botanical-online.com/plantas-medicinales/sen-cassia-propiedades-caracteristicas
Knoess, W., & Werner, C. (2018). Assessment report on Senna alexandrina Mill. (Cassia senna L.; Cassia angustifolia Vahl), folium and fructus. In European Medicines Agency.
Martínez-Costa, C., Ortuño, M. J. P., Ponce, B. A., Núñez Gómez, F., Martínez-Rodríguez, L., Franch, I. F., & Solanes, J. B. (2005). Estreñimiento funcional: estudio prospectivo y respuesta al tratamiento FUNCTIONAL CONSTIPATION: PROSPECTIVE STUDY AND TREATMENT RESPONSE Objective. In An Pediatr (Barc) (Vol. 63, Issue 5).
Molina Arias, M., & Ortega Páez, E. (2013). Avances en terapéutica Tratamiento del estreñimiento en el niño Puntos clave. Avances En Terapéutica, 11, 342–345.
Nurko, S., & Zimmerman, L. A. (2014). Evaluation and Treatment of Constipation in Children and Adolescents. American Family Physician, 90(2). http://familydoctor.org/
P. Henríquez, J., & Núñez Ramos, S. (2020). MANEJO DE LOS PACIENTES PEDIATRICOS CON ESTREÑIMIENTO FUNCIONAL. Universidad Nacional Pedro Henríquez Ureña.
Pediamécum, A. (2020). Senósidos A y B. Pediamécum AEP. http://www.aemps.gob.es/cima.
Santos Jasso, K. A., Giorgis Stuven, M. A., Ruíz Montañez, A., Bañuelos Castañeda, C. J., & Torre Mondragón, L. (2014). Efectividad del programa de rehabilitación intestinal en niños con estreñimiento secundario a malformación anorrectal. Acta Pediátrica de Mexico, 35, 111–117.
Vilanova-Sanchez, A., Gasior, A. C., Toocheck, N., Weaver, L., Wood, R. J., Reck, C. A., Wagner, A., Hoover, E., Gagnon, R., Jaggers, J., Maloof, T., Nash, O., Williams, C., & Levitt, M. A. (2018). Are Senna based laxatives safe when used as long term treatment for constipation in children? Journal of Pediatric Surgery, 53(4), 722–727. https://doi.org/10.1016/j.jpedsurg.2018.01.002
Villalva Valencia, S. V. (2021). Análisis de los principios bioactivos medicinales de las hojas de Senna alexandrina Mill. UNIVERSIDAD TÉCNICA DE AMBATO.
Vogel, A. (2024, May 15). Cassia angustifolia. A Vogel Enciclopedia de Plantas.
Watanabe, J., & Kotani, K. (2021). Polyethylene Glycol Versus Senna for Bowel Preparation for Colonoscopy in Children: Updated Evidence by a Systematic Review and Meta-Analysis. Cureus. https://doi.org/10.7759/cureus.17813
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
The journal is licensed under the Attribution License (CC BY), allowing the possibility of copying, distributing, displaying, and producing derivative works, as long as the author is acknowledged and cited.
